2021 JCI European Conference on a cruise ship was always going to be a challenge, even without a pandemic. However, COVID-19 is posing as the greatest challenge so far. For a long time to come, the planning of events will involve an increased amount of uncertainty. We believe that current developments in Germany and in most European Countries indicate that the 2021 JCI European conference will be able to take place as planned. Although this pandemic is far from over, the number of new infections in most European Countries is considerably lower than at its peak and is further decreasing. We sincerely hope this trend continues, but it could also change. To use a famous quote: “It is difficult to make predictions, especially about the future!”